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Abstract #2933

Intracellular sodium imaging in the brain via short-T2 component in bound sodium

Yongxian Qian 1 , Ashok Panigrahy 2 , Charles M. Laymon 1 , Vincent K. Lee 2 , Jan Drappatz 3 , Frank S. Lieberman 3 , Fernando E. Boada 4 , and James M. Mountz 1

1 Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2 Radiology, Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 3 Neurology, University of Pittsburgh, Pittsburgh, PA, United States, 4 Radiology, New York University, New York, New York, United States

This work presents an alternative to triple-quantum filtering (TQF) techniques for quantifying intracellular sodium concentration (ISC) on clinical 3T MRI scanners with a much shorter scan time under SAR restriction. The new technique acquires two single-quantum (SQ) sodium images at ultrashort and long echo times (TE=0.44 and 5 ms) respectively, and then subtracts them to attain the short-T2 component intensity in the bi-exponential T2 relaxation of bound sodium. The experiments on phantoms and brain tumor patients showed the feasibility of the proposed idea.

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