Abstract #2933
Intracellular sodium imaging in the brain via short-T2 component in bound sodium
Yongxian Qian 1 , Ashok Panigrahy 2 , Charles M. Laymon 1 , Vincent K. Lee 2 , Jan Drappatz 3 , Frank S. Lieberman 3 , Fernando E. Boada 4 , and James M. Mountz 1
1
Radiology, University of Pittsburgh,
Pittsburgh, PA, United States,
2
Radiology,
Childrens Hospital of Pittsburgh of UPMC, Pittsburgh,
PA, United States,
3
Neurology,
University of Pittsburgh, Pittsburgh, PA, United States,
4
Radiology,
New York University, New York, New York, United States
This work presents an alternative to triple-quantum
filtering (TQF) techniques for quantifying intracellular
sodium concentration (ISC) on clinical 3T MRI scanners
with a much shorter scan time under SAR restriction. The
new technique acquires two single-quantum (SQ) sodium
images at ultrashort and long echo times (TE=0.44 and 5
ms) respectively, and then subtracts them to attain the
short-T2 component intensity in the bi-exponential T2
relaxation of bound sodium. The experiments on phantoms
and brain tumor patients showed the feasibility of the
proposed idea.
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