Abstract #2906
Comparison of the Repeatability of GABA-Edited Magnetic Resonance Spectroscopy with and without Macromolecule Suppression
Mark Mikkelsen 1 , Petroc Sumner 1 , Krish D. Singh 1 , and C. John Evans 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, United Kingdom
In vivo quantification of the inhibitory
neurotransmitter γ-aminobutyric acid (GABA) is possible
with J-difference edited proton magnetic resonance
spectroscopy (MRS), but concentration measurements
suffer from macromolecule (MM) contamination. This is a
result of a co-edited MM resonance being partially
excited during acquisition. Using symmetric
editing-based suppression, however, the MM signal can be
suppressed. Here, the repeatability of GABA-edited MRS
with and without MM suppression is evaluated and
compared. It is shown that MM suppression is comparable
in repeatability to standard GABA-editing. MM-suppressed
GABA measurement offers increased measurement
specificity and potentially an increased ability to
discriminate between participants.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
