Abstract #2905
The Influence of Bold-fMRI (GRE-EPI) on MEGA-PRESS Measurements of GABA Concentrations
Sofie Tapper 1 , Anders Tisell 1,2 , and Peter Lundberg 1,2
1
Radiation Physics, Department of Medicine
and Healths Sciences, Linkping University, Linkping
University, Linkping, Sweden,
2
Centre
for Medical Image Science and Visualization (CMIV),
Linkping University, Linkping, Sweden, Linkping
University, Linkping, Sweden
In many recent experiments BOLD-fMRI has been combined
with quantitative measurements of GABA-concentrations in
order to elucidate the correlation between positive or
negative BOLD and GABA and Glutamate concentrations in
connection with a range of diseases affecting the CNS.
GABA MRS is in many cases performed subsequent to the
fMRI data-acquisition. As a consequence, the quality of
the GABA-measurements heavily depend on the short term
stability of the MR-scanner. Our aim was to determine
the possibly deleterious effects a BOLD-fMRI (GRE-EPI)
experiment had on the stability of MEGA-PRESS
measurements, and we have performed investigations of
the drift in synthesizer frequency and phase. All
measurements were performed both before and after GRE-EPI.
The conclusion was that the large influence of EPI-induced
gradient heating on quantitative GABA-concentration
measurements needs to be corrected for using a procedure
taking both the frequency- and phase-drift in each
individual dynamic into account.
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