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Abstract #2907

Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3T

Petr Bednarik 1,2 , Amir Moheet 1 , Dinesh K Deelchand 1 , Uzay E Emir 3 , Elizabeth R Seaquist 1 , and Gulin Oz 1

1 University of Minnesota, Minneapolis, MN, United States, 2 Central Europeran Institute of Technology, Masaryk University, Brno, Czech Republic, 3 FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Hippocampus dysfunction may be involved in multiple neurologic and neuropsychiatric diseases. We investigated the feasibility of obtaining high quality hippocampal spectra and the test-retest reproducibility of hippocampal neurochemical profiles using standard 3T hardware with an in-house implemented single-voxel, short-echo semi-LASER sequence. Neurochemical profiles were highly reproducible between subjects (N=6) and between sessions (each subject scanned twice). Six metabolites were quantified with mean CRLB ≤ 10% and another 4 with CRLB ≤ 30%. Mean intersession CV was <10% for 8 metabolites. This methodology will allow novel investigations of hippocampal neurochemistry in many common clinical conditions with widely available hardware.

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