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Abstract #2871

Echo planar spectroscopic imaging based temperature calibration at 7T and 3T for whole brain temperature measurement in rodents and humans

Bhanu Prakash KN 1 , Sanjay K Verma 1 , Yevgen Marchenko 1 , Sankar Seramani 1 , Suresh Anand Sadananthan 2 , Navin Michael 2 , Charmaine Childs 3 , Lu Jia 4 , Andrew A. Maudsley 5 , and Sendhil Velan S 1,6

1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2 Singapore Institute for Clinical Sciences, Singapore, Singapore, 3 Centre for Health and Social Care Research, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, United Kingdom, 4 Combat Protection and Performance Lab, Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore, 5 Miller School of Medicine, University of Miami, Miami, Florida, United States, 6 Clinical Imaging Research Centre, Singapore, Singapore

Whole brain temperature mapping is of great interest for investigating traumatic brain injuries. Single-voxel-spectroscopy (SVS) and CSI approaches provides limited spatial coverage in the brain, whereas 3D Echo-planar spectroscopic imaging (EPSI), covers the entire brain for investigating temperature and metabolism in traumatic brain injury (TBI) subjects. Our study aims at implementation of EPSI, calibration and validation of the temperature measurement in brain phantoms using EPSI and SVS at pre-clinical and clinical scanners, to study and analysis of whole brain temperature in TBI studies on rodents and humans.

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