Abstract #2870
Shrinking microfabricated multispectral MRI contrast agents to the nanoscale
Gary Zabow 1,2 , Stephen Dodd 1 , John Moreland 2 , and Alan Koretsky 1
1
NINDS, NIH, Bethesda, Maryland, United
States,
2
Physical
Measurements Division, NIST, Boulder, Colorado, United
States
Newly developed microfabricated multispectral MRI agents
offer multispectral contrast that is tunable over broad
frequency ranges allowing for the possibility of highly
multiplexed imaging. However, such agents has thus far
been limited by their relatively large sizes. To
overcome this limitation and expand their biological
utility, this work shows how it is possible to shrink
these agents to sub-micron and nano size scales. The
nanofabrication techniques involved, and the NMR
spectral signatures that result from agents over a 100
times less massive than any previously published
equivalent are presented, and future benefits and limits
to further agent miniaturization are discussed.
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