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Abstract #2872

semi-LASER 1 H MR Spectroscopy at 7T in Human Brain: Metabolite Quantification Incorporating Subject-Specific Macromolecule Removal

Jacob Penner 1,2 and Robert Bartha 1,2

1 Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, Ontario, Canada, 2 Medical Biophysics, Western University, London, Ontario, Canada

Magnetic resonance spectroscopy suffers from inherent low sensitivity; it is advantageous to increase the magnetic field strength and therefore the signal-to-noise ratio. The purpose of this study was to develop a 7 Tesla in vivo short echo time semi-LASER MR spectroscopy protocol incorporating subject-specific macromolecule removal, yielding absolute metabolite concentrations. MRS data were obtained from the parietal-occipital region of five young healthy volunteers. Absolute levels were in good agreement with previous studies that reported in vivo metabolite concentrations at 7 Tesla in young healthy subjects. Therefore, this protocol is suitable for measuring metabolic changes in neuropathological conditions.

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