Abstract #2872
semi-LASER 1 H MR Spectroscopy at 7T in Human Brain: Metabolite Quantification Incorporating Subject-Specific Macromolecule Removal
Jacob Penner 1,2 and Robert Bartha 1,2
1
Centre for Functional and Metabolic Mapping,
Robarts Research Institute, London, Ontario, Canada,
2
Medical
Biophysics, Western University, London, Ontario, Canada
Magnetic resonance spectroscopy suffers from inherent
low sensitivity; it is advantageous to increase the
magnetic field strength and therefore the
signal-to-noise ratio. The purpose of this study was to
develop a 7 Tesla in vivo short echo time semi-LASER MR
spectroscopy protocol incorporating subject-specific
macromolecule removal, yielding absolute metabolite
concentrations. MRS data were obtained from the
parietal-occipital region of five young healthy
volunteers. Absolute levels were in good agreement with
previous studies that reported in vivo metabolite
concentrations at 7 Tesla in young healthy subjects.
Therefore, this protocol is suitable for measuring
metabolic changes in neuropathological conditions.
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