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Abstract #2851

Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging

Sophie Laurent 1 , Dimitri Stanicki 1 , Sebastien Boutry 2 , Ludivine Wacheul 2 , Emilien Nicolas 2 , Deborah Crombez 1 , Luce Vander Elst 1 , Denis Lafontaine 2,3 , and Robert N Muller 1,2

1 General, Organic and Biomedial Chemistry, NMR and Molecular Imaging Laboratory, UMONS, MONS, Hainaut, Belgium, 2 Center for Microscopy and Molecular Imaging, Hainaut, Belgium, 3 Laboratory of RNA Metabolism, ULB, Brussels, Belgium

This study reports the synthesis of USPIO as bimodal probes for magnetic resonance and optical imaging. These nanosystems are based on small iron oxide cores surrounded by a thin polysiloxane shell exhibiting carboxylic acid functions. Thanks to these functions, hybrid particles were obtained by conjugating a fluorophore to the superparamagnetic contrastophore. Such modification allowed directly following these USPIO in cellulo, which provided interesting information about their internalization pathway and cellular distribution upon mitosis. Finally, their efficiency as probes for bimodal imaging was emphasized by the observation of their in vivo behavior in mice using magnetic resonance and optical imaging.

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