Abstract #2852
Gd-Complexes of DO3A-benzothiazole Conjugate for MRI Theragnostic Agents
Ki-Hye Jung 1 , Hee-Kyung Kim 2 , Min-Kyoung Kang 2 , Soyeon Kim 2 , Hyun-Jeong Jeong 2 , Garam Choi 2 , Ji-Ae Park 3 , Eun-Young Jeon 4 , Tae-Jeong Kim 1 , and Yongmin Chang* 2,5
1
Department of Applied Chemistry, Kyungpook
National University, Daegu, Korea,
2
Department
of Medical & Biological Engineering, Kyungpook National
University, Daegu, Korea,
3
Molecular
Imaging Research Center, Korea Institute of Radiological
& Medical Science, Seoul, Korea,
4
Institute
of Biomedical Engineering, Kyungpook National
University, Daegu, Korea,
5
Department
of Diagnostic Radiology and Molecular Medicine,
Kyungpook National University, Daegu, Korea
We report the synthesis of
1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid
(DO3A) derivatives of benzothiazole and their Gd(III)
complexes of the type [Gd(DO3A-BTA)(H
2
O)] (
2a
,
b
)
for use as a single molecule theranostic agent. The
complexes are not only tumor-specific but also
intracellular, enhancing MR images of cytosols and
nuclei of tumor cells such as MCF-7, MDA-MB-231,
SK-HEP-1, HeLa, and Caki-2.
2a
and
2b
reveal
antiproliferative, activities as demonstrated by GI
50
and
TGI values obtainable form the cell counting kit-8
(CCK-8) assays performed on these cell lines.
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