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Abstract #2850

Synthesis and characterization of multi-layered hybrid gold-iron oxide superparamagnetic nanoparticles.

Alexei Bogdanov, Jr 1 , Mohammed S Shazeeb 1 , Lejie Zhang 2 , and Surong Zhang 1

1 Radiology, UMASS Medical School, Worcester, MA, United States, 2 Biochemical Pharmacology, UMASS Medical School, Worcester, MA, United States

We developed a strategy enabling synthesis of hybrid iron-oxide gold nanoparticles with very high molar relaxivity in water. Silver-tagged dextran-stabilized iron oxides (IO-Ag) were formed by reacting iron oxides in the presence of diamminesilver(I) nitrate. Incubation of IO-Ag in the presence of tetrachloroauric acid and citrate resulted in the formation of electron dense single-core negatively charged IO-Ag-Au which were stabilized using MPEG-gPLL resulting in stable 65 nm nanoparticles. At 3T, the increase of r2 allowed improving the detectability level by a factor of 10. The obtained nanoparticles could be targeted using antibody fragments and were forming complexes with oligonucleotide duplexes.

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