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Abstract #2849

Dendrimersomes: a new vesicular nanoplatform for theranostic applications

Miriam Filippi 1 , Marisa Ferraretto 1 , Gilberto Mulas 1 , Jonathan Martinelli 2 , Lorenzo Tei 2 , Mauro Botta 2 , Silvio Aime 1,3 , and Enzo Terreno 1,3

1 Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Turin, Italy, 2 Department of Sciences and Technological Innovation, University of Eastern Piedmont 'A. Avogadro', Alessandria, Italy, 3 Center for Preclinical Imaging, University of Turin, Colleretto Giacosa, Turin, Italy

The potential of newly developed nanovesicles, named dendrimersomes, as MRI reporters was investigated by encapsulating the contrast agent Gadoteridol inside the aqueous core or by incorporating a novel dendrimer covalently conjugated to a Gd-complex into the vesicular bilayered membrane. Due to the high membrane permeability, longitudinal relaxivity of encapsulated probes was subjected only to a limited quenching effect. On the other hand, membrane-incorporated probes showed higher relaxivity values that are typical of slowly rotating Gd-chelates. Stability and imaging studies suggested that dendrimersomes may have the potential to act as efficient diagnostic/theranostic MRI agents.

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