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Abstract #2848

Development of a surface-switching theranostic lipid-PLGA hybrid nanoparticle platform

Line Hansen 1,2 , Francois Fay 1 , Anita Gianella 1 , Pedro Ramos-Cabrer 1 , Bram Priem 1 , Brenda Sanchez 1 , Aneta J. Mieszawska 1 , Robert Langer 3 , Jrgen Kjems 2 , Zahi A. Fayad 1 , and Willem J. M. Mulder 1

1 Translational and Molecular Imaging Institute at Icahn School of Medicine, Mount Sinai, New York, NY, United States, 2 Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, Denmark, 3 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States

Surface-swtichable lipid/PLGA hybrid nanoparticles with an MMP-2 cleavable PEG coating were developed. To enable near infrared optical imaging and MRI, Cy5.5 dyes and Gd-DPTA-lipids were incorporated in their polymeric core and lipid corona, respectively. In vitro studies were performed to show the protease-induced switching and utility of this multifunctional nanoparticle platform.

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