Meeting Banner
Abstract #2838

Quantitative 19 F MRI and CT Tracking of Microencapsulated Stem Cells in a Rabbit Peripheral Arterial Disease Model

Guan Wang 1,2 , Yingli Fu 1 , Shashank Sathyanarayana Hegde 1 , Steven M. Shea 3 , and Dara L. Kraitchman 1,4

1 Russell H. Morgan Dept. of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, 2 Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, 3 Corporate Technology, Siemens Corporation, Baltimore, MD, United States, 4 Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, United States

Nearly 12% of Americans suffer from peripheral arterial disease (PAD) with stem cell therapies providing a new alternative treatment for the most severe cases. Microencapsulated stem cells (SCs) offer a novel means to transplant mismatched cells to avoid immunorejection and enable tracking using conventional imaging modalities. Using a rabbit model of PAD, we determine the ability of c-arm CT and MRI to serially measure capsule persistence and concentration in an immunocompetent rabbit after xenogenic (Xeno) or allogenic (Allo) SC microcapsule delivery. XenoSCs were as well tolerated as AlloSCs and could be accurately and reproducibly tracked by CT and MRI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here