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Abstract #2837

Deuterium prolonged relaxation reveals the macromolecular content in MRI

Chin-Tien Lu 1 , Chih-Ching Lai 1 , Sheng-Min Huang 1 , and Fu-Nien Wang 1

1 Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

Recently, the deuterium oxide(D 2 O) has been used as a negative contrast agent for perfusion imaging by indirectly monitoring the infused deuterium via the conventional protonium imaging. It is also noticed that the H/D isotope exchange effect of deuterium can prolong the T 1 and T 2 relaxation of protonium. In this study, we aimed to investigate the contrast mechanism in an environment with macromolecules. The r 1 relaxivity of D 2 O is nearly irrelevant to BSA concentration, while the r 2 has a linear correlation with BSA concentration. It is found that the contrast mechanism is sensitive to the macromolecular content.

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