Abstract #2837
Deuterium prolonged relaxation reveals the macromolecular content in MRI
Chin-Tien Lu 1 , Chih-Ching Lai 1 , Sheng-Min Huang 1 , and Fu-Nien Wang 1
1
Department of Biomedical Engineering and
Environmental Sciences, National Tsing Hua University,
Hsinchu, Taiwan
Recently, the deuterium oxide(D
2
O) has been
used as a negative contrast agent for perfusion imaging
by indirectly monitoring the infused deuterium via the
conventional protonium imaging. It is also noticed that
the H/D isotope exchange effect of deuterium can prolong
the T
1
and
T
2
relaxation
of protonium. In this study, we aimed to investigate the
contrast mechanism in an environment with
macromolecules. The r
1
relaxivity
of D
2
O is nearly irrelevant to BSA
concentration, while the r
2
has
a linear correlation with BSA concentration. It is found
that the contrast mechanism is sensitive to the
macromolecular content.
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