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Abstract #2836

Tetra-manganese Polyoxometalates: a new candidate contrast agent for MRI

Xiaoyong Zhang 1 , Jie Song 1 , Sha Wang 1 , Brenda Robledo 1 , Craig L Hill 2 , Shuming Nie 1 , and Xiaoping Hu 1

1 Department of Biomedical Engineering, Emory University, Atlanta, Georgia, United States, 2 Department of Chemistry, Emory University, Atlanta, Georgia, United States

The purpose of this work was to synthesize a new tetramanganese cluster in a POM chelate frame named tetra-manganese Polyoxometalates (Mn4POM) and to evaluate its application as a contrast agent for MRI. X-ray single crystal diffraction showed Mn4POM has the tetra-manganese (Mn4) core within its crystal structure. When cells were exposed to low concentrations of Mn4POM, no cytotoxicity was caused. MRI demonstrated that cells incubated with Mn4POM showed significant increase in R1, compared with cells incubated with MnCl2. Our results indicate Mn4POM is a new candidate contrast agent with better MR contrast than free Mn2+, likely due to the Mn4 core within its crystal structure, suggesting that Mn4POM may also be used for in vivo contrast enhancement.

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