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Abstract #2835

Transcranial application of manganese chloride enables neuronal tract tracing using MEMRI

Tatjana Atanasijevic 1 , Theodore L. Roth 2 , Dorian B. McGavern 2 , and Alan P. Koretsky 1

1 LFMI, NINDS, NIH, Bethesda, MD, United States, 2 NINDS, NIH, Bethesda, MD, United States

There has been increased interest in neuronal tract tracing using Manganese Enhanced Magnetic Resonance Imaging (MEMRI). Typically manganese chloride is administered to an animal by direct injection into the brain. Here it is demonstrated that manganese chloride solution can diffuse through the rat scull bone when applied directly on the exposed scull. Signal enhancement has been observed in the expected neuronal pathway. This offers the possibility of much less invasive manganese delivery method for MEMRI.

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