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Abstract #2834

Variations in intra- and extracellular water component differentiation using intrathecal and subcutaneous injections of manganese chloride

Mohammed Salman Shazeeb 1,2

1 Radiology, University of Massachusetts Medical School, Worcester, MA, United States, 2 Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, United States

Diffusion-weighted NMR techniques have established that the ADC of cerebral tissue water decreases during ischemia. However, it remains unclear whether the ADC change occurs due to changes in the intracellular (IC) space, extracellular (EC) space, or both. Past works have measured compartment-specific diffusion coefficients using gadolinium as an EC MR contrast agent which reduces the longitudinal (T1) relaxation time of the EC space. In this study, we investigate an alternative approach by using manganese (Mn2+), which acts as a calcium analogue. Mn2+ uptake by cells causes T1 of IC water to shorten, thus allowing differentiation between the compartmental MR signals.

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