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Abstract #2839

Correlation of glucose metabolism and apparent diffusion coefficient of malignant disease evaluated with simultaneous hybrid PET/MRI

Jianhua Yan 1 , Jason Chu-Shern Lim 1 , Hoi Yin Loi 2 , Ivan WK Tham 1,3 , John James Totman 1 , Arvind Kumar Sinha 2 , Swee Tian Quek 2 , and David W Townsend 1,2

1 A*STAR-NUS, Clinical Imaging Research Center, Singapore, Singapore, Singapore, 2 Department of Diagnostic Radiology, National University Hospital, Singapore, Singapore, 3 National University Cancer Institute, Singapore, Singapore

Positron emission tomography (PET) with [18F]flurodeoxyglucose (FDG) provides quantitative information regarding cellular glucose metabolism. The standardized uptake value (SUV) is commonly used to evaluate tumor glucose metabolism, which is biomarker for clinical diagnosis of tumor malignancy, disease recurrence, and metabolic response to therapy. Diffusion-weighted MRI (DWI) is also increasingly used in the evaluation of malignant disease. By combining two or more images of the same area with different diffusion weighting, water movement can be quantified as the apparent diffusion coefficient (ADC) . Like the SUV from PET/CT, ADC has been used clinically to differentiate benign from malignant tumors and to assess tumor grade, delineate tumor extent and predict survival3. Results of several studies have suggested an inverse correlation between SUV and ADC across varying malignancies including the first study evaluated on a simultaneous PET/MRI hybrid imaging system4, which has the capability of eliminating registration error due to separate PET/CT and MRI examinations and minimizing potential physiological and treatment changes due to the time interval between the PET and MRI examinations. The purpose of this study is to continue to investigate whether FDG-PET and ADC have significant correlation evaluated on simultaneous PET/MRI.

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