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Abstract #2829

Validation of MRI Mn Concentration Mapping in the Rat Brain

Geoffrey Topping 1 , Andrew Yung 2 , Paul Schaffer 3 , Cornelia Hoehr 3 , Thomas Ruth 3 , Piotr Kozlowski 2 , and Vesna Sossi 1

1 Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada, 2 MRI Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, 3 Nuclear Medicine, TRIUMF, Vancouver, British Columbia, Canada

Live rats given single injections containing both MnCl2 and Mn-52, and their brains imaged with MRI R1 relaxation rate mapping, as well as positron emission tomography. Post mortem, autoradiographs were also acquired of ex vivo brain slices. Per-voxel differences between baseline and post-injection R1 were converted to Mn concentration using an in vitro derived Mn relaxivity calibration factor. Excellent quantitative agreement between PET and MRI was observed, indicating Mn MRI can produce accurate Mn concentration maps in live rat brain, although although localized discrepancies were observed at high Mn concentrations or when other factors affected the relaxation rate.

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