Abstract #2829
Validation of MRI Mn Concentration Mapping in the Rat Brain
Geoffrey Topping 1 , Andrew Yung 2 , Paul Schaffer 3 , Cornelia Hoehr 3 , Thomas Ruth 3 , Piotr Kozlowski 2 , and Vesna Sossi 1
1
Physics and Astronomy, University of British
Columbia, Vancouver, British Columbia, Canada,
2
MRI
Research Centre, University of British Columbia,
Vancouver, British Columbia, Canada,
3
Nuclear
Medicine, TRIUMF, Vancouver, British Columbia, Canada
Live rats given single injections containing both MnCl2
and Mn-52, and their brains imaged with MRI R1
relaxation rate mapping, as well as positron emission
tomography. Post mortem, autoradiographs were also
acquired of ex vivo brain slices. Per-voxel differences
between baseline and post-injection R1 were converted to
Mn concentration using an in vitro derived Mn relaxivity
calibration factor. Excellent quantitative agreement
between PET and MRI was observed, indicating Mn MRI can
produce accurate Mn concentration maps in live rat
brain, although although localized discrepancies were
observed at high Mn concentrations or when other factors
affected the relaxation rate.
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