Meeting Banner
Abstract #2830

Manganese-enhanced MRI combined with acoustic startle reflex testing would be useful as an imaging biomarker for tinnitus

Mun Han 1 , Da Jung Jung 2 , Kyu Yup Lee 2 , Yongmin Chang* 1,3 , and Hui Joong Lee* 4

1 Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, 2 Department of Otorhinolaryngology & Head and Neck surgery, Kyungpook National University, Daegu, Korea, 3 Department of Radiology & Molecular Medicine, Kyungpook National University, Daegu, Korea, 4 Department of Radiology, Kyungpook National University, Daegu, Korea

Animal models continue to improve our understanding of tinnitus pathogenesis and aid in development of new diagnosis. However, there are no diagnostic biomarkers for tinnitus-related pathophysiology for use in animal. To address this disparity, two complementary methods were combined to examine reliable tinnitus models: manganese-enhanced MRI (MEMRI) and inhibition of the acoustic startle reflex (ASR) test. Salicylate-induced tinnitus resulted in many manganese uptake compared to normal model. Relative to that in controls, high signal intensity is shown in the areas of the cochlea and cochlear nucleus in salicylate group, displaying clear difference in six hour and twelve hour MEMRI image. Our results provide the foundation for future studies correlating the longevity of tinnitus with neuronal activity in the cochlea and specific brain regions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here