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Abstract #2828

Odorant stimulation manganese enhanced MRI for olfactory pathway after intranasal manganese administration

Byungmok Kim 1 , Mun Han 1 , Yongmin Chang 1,2 , and Hui Joong Lee* 3

1 Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Korea, 2 Department of Radiology & Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, Korea, 3 Department of Radiology, Kyungpook National University, Daegu, Korea

The aim of this study is to investigate the central nervous system (CNS) delivery of manganese following intranasal administration form the nasal passage to the CNS, response to different olfactory stimulants. Olfactory bulb in the signal intensity increased about Formic acid and Linalool. Acetone, Normal saline reduced the signal intensity, but there was statistically difference about four stimuli. Change of signal intensity on cerebral cortex, amygdale, pons and cerebellum showed statistical differences according to four stimuli (P<0.05). In conclusion, manganese-enhanced MRI revealed different manganese uptake on olfactory pathway according to different olfactory stimuli, which suggest activity-induced manganese-dependent MRI of olfactory pathway dependant on olfactory function.

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