Meeting Banner
Abstract #2821

The effect of loading nascent HDL with gadolinium phospholipids in the structural stability of the particles

Pedro Ramos-Cabrer 1,2 , Francois Fay 1 , Brenda L. Snchez-Gaytan 1 , Teresa Arias 3,4 , Jun Tang 1 , Jos Castillo 2 , Valentn Fuster 3,4 , Zahi A Fayad 1 , and Willem J. M. Mulder 1

1 Translational and Molecular Imaging Institute (TMII), Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2 Department of Neurology, Clinical Neurosciences Research Laboratory, University Clinical Hospital of Santiago, Health Sciences Institute of Santiago (IDIS), Santiago de Compostela, Spain, 3 Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

Labeling of bio-mimicking molecules such as HDL lipoprotein with imaging probes is a very interesting feature of molecular imaging techniques. However, self-aggregating systems are formed under delicate balances of non-covalent molecular interactions that are modified by the introduction of imaging probes. Here we describe how, over certain thresholds, the introduction of high amounts of a gadolinium loaded lipids in nascent HDL nanoparticles do not further increase the magnetic relaxivities of HDL (as desired), but lead in turn to the formation of large aggregates, that no longer can be defined as HDL, and that will potentially present different in vivo properties.

This abstract and the presentation materials are available to members only; a login is required.

Join Here