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Abstract #2820


Michael Oluwaseun Dada 1 , Bamidele Omotayo Awojoyogbe 1 , Simona Baroni 2 , and Samarendra Mohanty 3

1 Department of Physics, Federal University of Technology, Minna, Niger State, Nigeria, 2 Invento Laboratory, Molecular Biotechnology Center (MBC), Torino, Turin, Italy, 3 Department of Physics, Biophysics and Physiology group, University of Texas, Arlington, Texas, United States

Sickle cell disease (SCD) is an inherited disorder of hemoglobin structure that has no established cure in adult patients. The most important pathophysiologic event in sickle cell anemia, which explains most of its clinical manifestations, is vascular occlusion; this may involve both the micro- and macrovasculature1. The primary process that leads to vascular occlusion is the polymerization of sickle hemoglobin (Hb) on deoxygenation, which in turn results in distortion of the shape of red blood cells (RBC), cellular dehydration, and decreased deformability and stickiness of RBC, which promotes their adhesion to and activation of the vascular endothelium1. SCD has been regarded as a molecular disease without any established cure. Finding a realiable cure for this disease may be dependent on much we know about the molecular processes that lead to it and how we could possibly represent them in terms of images for classical observation. This study presents a contribution to the understanding of SCD using the Bloch Torrey equation so that we can easily represent the associated chemical processes in MRI images. Vascular occlusion is used to describe any form of blockage to blood vessels.

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