Abstract #2816
Thermosensitive biodegradable hydrogels for sustained delivery of therapeutic proteins: MRI-based monitoring of in vitro and in vivo protein release
Geralda A.F. van Tilborg 1 , Pavel Yanev 1 , Kristel W.M. Boere 2 , Tina Vermonden 2 , Annette van der Toorn 1 , Wim E. Hennink 2 , and Rick M. Dijkhuizen 1
1
Biomedical MR Imaging and Spectroscopy
Group, Image Sciences Institute, University Medical
Center Utrecht, Utrecht, Netherlands,
2
Department
of Pharmaceutics, Utrecht Institute for Pharmaceutical
Sciences, University Utrecht, Utrecht, Netherlands
Hydrogels have been suggested as novel drug carrier
system for sustained release of therapeutic proteins in
several disorders, including stroke. This study shows
that biodegradable hydrogels, consisting of
thermosensitive triblock polymers and thiolated
hyaluronic acid, release ≥ 80% of their
gadolinium-labeled albumin load within 2 days, both in
vitro and in the brain of living animals. The presented
MRI setup provides a unique opportunity to
non-invasively monitor protein delivery to the brain
through implanted hydrogels in living animals, which
could aid in the development and assessment of such
innovative drug carrier systems for prolonged drug
delivery to injured brain tissue.
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