Abstract #2815
Investigation of Vertical Translatability of Awake Pharmacological MRI in Non-Human Primate - A Buprenorphine Challenge Study
Stephanie Seah 1 , Abu Bakar Ali Asad 1 , Richard Baumgartner 2 , Dai Feng 2 , Donald S. Williams 3 , Elaine Manigbas 4 , John D. Beaver 4 , Torsten Reese 1 , Brian Henry 1 , Jeffrey L. Evelhoch 3 , and Chih-Liang Chin 1
1
Translational Medicine Research Centre, MSD,
Singapore, Singapore,
2
Biometrics
Research, BARDS, Merck & Co. Inc, Rahway, New Jersey,
United States,
3
Imaging,
Merck & Co. Inc, West Point, Pennsylvania, United
States,
4
Imaging,
Maccine Pte Ltd, Singapore, Singapore
We have established an awake non-human primate (NHP)
imaging platform and exploited it to delineate brain
activities elicited by buprenorphine (0.03 mg/kg iv)
under awake and anesthetized phMRI. We found
buprenorphine significantly activated brain regions
including, thalamus, striatum, frontal and cingulate
cortices (paired t-test, versus saline vehicle, p<0.05,
n=4) in awake NHPs, whilst no significant change was
observed under anesthetized imaging. Additionally,
activated brain areas agree with
-opioid
receptor distribution depicted by [6-O-[
11
C]methyl]buprenorphine
([
11
C]BPN) PET study in baboons and previous
buprenorphine phMRI data in human and conscious rats.
Our work highlights the utility of awake NHP phMRI for
translational research.
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