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Abstract #2815

Investigation of Vertical Translatability of Awake Pharmacological MRI in Non-Human Primate - A Buprenorphine Challenge Study

Stephanie Seah 1 , Abu Bakar Ali Asad 1 , Richard Baumgartner 2 , Dai Feng 2 , Donald S. Williams 3 , Elaine Manigbas 4 , John D. Beaver 4 , Torsten Reese 1 , Brian Henry 1 , Jeffrey L. Evelhoch 3 , and Chih-Liang Chin 1

1 Translational Medicine Research Centre, MSD, Singapore, Singapore, 2 Biometrics Research, BARDS, Merck & Co. Inc, Rahway, New Jersey, United States, 3 Imaging, Merck & Co. Inc, West Point, Pennsylvania, United States, 4 Imaging, Maccine Pte Ltd, Singapore, Singapore

We have established an awake non-human primate (NHP) imaging platform and exploited it to delineate brain activities elicited by buprenorphine (0.03 mg/kg iv) under awake and anesthetized phMRI. We found buprenorphine significantly activated brain regions including, thalamus, striatum, frontal and cingulate cortices (paired t-test, versus saline vehicle, p<0.05, n=4) in awake NHPs, whilst no significant change was observed under anesthetized imaging. Additionally, activated brain areas agree with lower case Greek mu -opioid receptor distribution depicted by [6-O-[ 11 C]methyl]buprenorphine ([ 11 C]BPN) PET study in baboons and previous buprenorphine phMRI data in human and conscious rats. Our work highlights the utility of awake NHP phMRI for translational research.

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