Abstract #2808
Transverse Relaxation Rate (R2) Dependence on Interecho Time (2 ) in Gene-based Iron-labeled Cells
Casey Y. Lee 1,2 , R. Terry Thompson 1,2 , Frank S. Prato 1,2 , Donna E. Goldhawk 1,2 , and Neil Gelman 1,2
1
Medical Biophysics, Western University,
London, ON, Canada,
2
Imaging
Program, Lawson Health Research Institute, London, ON,
Canada
We have investigated the dependence of transverse
relaxation rate (R2) on interecho time (2τ) in cells
labeled with iron using expression of MagA, a putative
iron transport gene. This dependence was analyzed using
a mathematical model previously developed for
iron-containing tissues. The model provided values for
the spatial correlation length (distance scale of
microscopic magnetic field variation), in
iron-supplemented MagA-expressing cells, that were
smaller than those previously obtained in
iron-containing tissues. In addition to improving our
understanding of iron distribution in these systems, our
results should provide insight into the development of
more iron-specific strategies to detect these cells.
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