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Abstract #2808

Transverse Relaxation Rate (R2) Dependence on Interecho Time (2 ) in Gene-based Iron-labeled Cells

Casey Y. Lee 1,2 , R. Terry Thompson 1,2 , Frank S. Prato 1,2 , Donna E. Goldhawk 1,2 , and Neil Gelman 1,2

1 Medical Biophysics, Western University, London, ON, Canada, 2 Imaging Program, Lawson Health Research Institute, London, ON, Canada

We have investigated the dependence of transverse relaxation rate (R2) on interecho time (2τ) in cells labeled with iron using expression of MagA, a putative iron transport gene. This dependence was analyzed using a mathematical model previously developed for iron-containing tissues. The model provided values for the spatial correlation length (distance scale of microscopic magnetic field variation), in iron-supplemented MagA-expressing cells, that were smaller than those previously obtained in iron-containing tissues. In addition to improving our understanding of iron distribution in these systems, our results should provide insight into the development of more iron-specific strategies to detect these cells.

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