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Abstract #2778

High-resolution 2D MRI of 1 H and 13 C hyperpolarized contrast agents at 0.0475 T

Aaron M. Coffey 1,2 , Roman V. Shchepin 2 , Danila A. Barskiy 3,4 , Kirill V. Kovtunov 3,4 , Igor V. Koptyug 3,4 , Kevin W. Waddell 2,5 , Ping He 6 , Kirsten A. Groome 6 , Quinn A. Best 6 , Fan Shi 6 , Boyd M. Goodson 6 , and Eduard Y. Chekmenev 1,2

1 Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2 Radiology, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 3 International Tomography Center, Novosibirsk, 630090, Russian Federation, 4 Novosibirsk State University, Novosibirsk, 630090, Russian Federation, 5 Physics, Vanderbilt University, Nashville, TN, United States, 6 Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL, United States

Nuclear spin polarization P is a key factor for MRI sensitivity, with various hyperpolarization techniques permitting orders of magnitude increases beyond that afforded by static magnetic fields. Low-field, resonance frequency optimized rf coils can allow imaging of such polarization with greater sensitivity than at high field. High-resolution 0.0475 T proton and 13 C 2D GRE imaging is demonstrated for pyridine and 13 C-succinate hyperpolarized via SABRE and PHIP respectively in a 5.75 mT parahydrogen polarizer. Proton in-plane resolution was 94 μm for P ~ 0.5%, and 13 C in-plane resolution was 250 μm with P ~ 13%.

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