Abstract #2779
In vivo Hyperpolarized 13C Chemical Shift Imaging using Variable Flip Angle and Centric Phase Encoding of Stimulated Mouse Muscle
Tangi Roussel 1 , Avigdor Leftin 1 , and Lucio Frydman 1
1
Department of Chemical Physics, Weizmann
Institute of Science, Rehovot, Israel
MR spectroscopic imaging of hyperpolarized 13C1-pyruvate
is a promising technique for in vivo mapping of
metabolic information. This method is based on dynamic
nuclear polarization (DNP) and on a rapid dissolution
process to produce a highly polarized metabolic contrast
agent. After injection, 13C1-pyruvate and its metabolic
products 13C1-lactate, 13C1-alanine and 13C1-bicarbonate
can be mapped using a Chemical Shift Imaging (CSI)
sequence. In this study, a Variable Flip Angle (VFA)
Centric Phase Encoding (CPE) CSI sequence was
implemented and applied on hyperpolarized 13C1-pyruvate
for imaging the metabolism of mice skeletal muscles
during functional stimulations mimicking exercise.
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