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Abstract #2774

Detection of Hyperpolarized [5-13C]-Glutamine in Brain

Concetta Valeria Gringeri 1,2 , Eugen Kubala 1,2 , Ulrich Koellisch 2,3 , Annette FranK 1 , Rolf Schulte 2 , Axel Haase 3 , Markus Schwaiger 1 , Steffen Glaser 4 , and Marion Irene Menzel 2

1 Institute of Nuclear Medicine, Klinikum rechts der Isar, TUM, Munich, Bayern, Germany, 2 GE Global Research, Munich, Bayern, Germany, 3 IMETUM, TUM, Munich, Bayern, Germany, 4 Department of Chemistry, TUM, Munich, Bayern, Germany

A change in neurotransmitter levels (glutamate, glutamine and GABA) was demonstrated recently in the striatum at Parkinsons disease models using 1H MRS. Glutamine is able to cross the BBB by facilitated diffusion, however compared to other neutral amino acids this process is slower. Therefore brain distribution of hyperpolarized [5-13C]-glutamine was imaged in Lewis healthy rats. A sufficient glutamine signal was detected in different brain areas. In the main future 13C-MRI might provide novel and more selective tools to study the transport systems and evaluate their regulation in vivo. In this sense hyperpolarized glutamine can be considered a promising candidate.

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