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Abstract #2773

Survival from Brain Metastasis of Breast Cancer is Inversely Correlated with Hyperpolarized 1-13C Lactate/Pyruvate ratio: Preliminary Study in Nude Mouse Model.

Young-suk Choi 1 , Joon-Sung Lee 2,3 , Han-Sol Lee 3 , Hyun-Jin Park 1 , Ju-Hyun Lee 1 , Eun-Kyung Wang 1 , Seung-Wook Yang 3 , Eun-Hae Joe 3 , Dong-Hyun Kim 3 , and Ho-Taek Song 1

1 Department of Radiology, Yonsei University College of Medicine, Seodaemun-Gu, Seoul, Korea, 2 SIRIC, Yonsei University College of Medicine, Seodaemun-Gu, Seoul, Korea, 3 Department of Eletrical & Electronic Engineering, Yonsei University, Seodaemun-Gu, Seoul, Korea

In brain metastasis from breast cancer mouse model, we evaluate the pyruvate to lactate conversion ratio to monitor the alteration of metabolism by metformin by hyperpolarized 13C metabolic MRS imaging. The inhibition of tumor growth by metformin was not proved by conventional imaging and hyperpolarized 13C MRSI. Individual conversion ratio of 13C pyruvate to 13C lactate showed inverse correlation with survival regardless of experimental group. Hyperpolarized 13C MRSI may be useful tool to predict the prognosis cancer patients.

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