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Abstract #2747

Prostate cancer localization by magnetic resonance dispersion imaging

Massimo Mischi 1 , Simona Turco 1 , Cristina Lavini 2 , Marcel Breeuwer 3 , Jean de la Rosette 4 , Mark Engelbrecht 2 , and Hessel Wijkstra 1,4

1 Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Radiology, Academic Medical Center University of Amsterdam, Netherlands, 3 Philips Healthcare, Netherlands, 4 Urology, Academic Medical Center University of Amsterdam, Netherlands

MR dispersion imaging (MRDI) is proposed as a new method for characterization of the microvascular architecture by assessment of contrast intravascular dispersion in DCE MRI. Dispersion is estimated by fitting a new model that integrates the Tofts model for extravascular leakage together with a solution of the convective-dispersion equation. Based on the established link between angiogenesis and cancer growth, this method is evaluated for localization of prostate cancer by comparison with histology results following radical prostatectomy. Without need for an arterial input function, MRDI enables accurate localization of prostate cancer, as confirmed by our initial validation with 90 MRI slices in 15 patients.

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