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Abstract #2746

Assessment of Scan-Rescan Variability in DCE-MRI Parameters Using Multiple Models

Edward Ashton 1 , Jean Tessier 2 , and Oliver Krieter 3

1 Imaging Science, VirtualScopics, Inc., Rochester, NY, United States, 2 F. Hoffman-La Roche Ltd., Basel, Switzerland, 3 Roche Diagnostics GmbH, Penzberg, Germany

This study examines the scan-rescan variability of five parameters obtainable from DCE-MRI scans. The analysis models examined are the Standard Tofts, Extended Tofts, and Distributed Parameter. Two model-free parameters are also reviewed. Data were acquired from six GBM patients, each scanned twice within a single week. Coefficients of variability were calculated for each of six parameters: KTrans (Standard Tofts), KTrans (Extended Tofts), PS (Distributed Parameter), as well as IAUC90 and AUCBN90, which do not require an analysis model. Results show KTrans (Standard) and AUCBN90 to be the least variable assessments, while PS shows the highest variability of the parameters studied.

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