Abstract #2738
Joint estimation of precontrast T 1 and DCE-MRI perfusion and permeability parameters significantly improves precision of parameter estimates
Ben R Dickie 1 , Anita Banerji 2,3 , Catharine M West 4 , and Chris J Rose 2,3
1
Christie Medical Physics and Engineering,
Christie Hospital, Manchester, Greater Manchester,
United Kingdom,
2
Centre
for Imaging Sciences, Manchester Academic Health Science
Centre, University of Manchester, Manchester, United
Kingdom,
3
Biomedical
Imaging Institute, University of Manchester, Manchester,
United Kingdom,
4
Institute
of Cancer Sciences, University of Manchester,
Manchester, United Kingdom
A novel method for estimating DCE-MRI parameters is
presented. Precontrast T1, M0, and model parameters are
estimated jointly, differing from current practice where
precontrast T1 and M0 are estimated prior to the model
parameters (sequentially). The precision of the two
methods were compared using a software phantom capable
of simulating realistic abdominal anatomy, contrast
enhancement (as modelled with the two-compartment
exchange model) and non-linear local motion. Joint
estimation led to significant improvements in the
precision for all model parameters. In data with motion
corruption, significant improvements in precision were
observed for estimates of plasma perfusion and relative
interstitial volume only.
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