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Abstract #2738

Joint estimation of precontrast T 1 and DCE-MRI perfusion and permeability parameters significantly improves precision of parameter estimates

Ben R Dickie 1 , Anita Banerji 2,3 , Catharine M West 4 , and Chris J Rose 2,3

1 Christie Medical Physics and Engineering, Christie Hospital, Manchester, Greater Manchester, United Kingdom, 2 Centre for Imaging Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 3 Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, 4 Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom

A novel method for estimating DCE-MRI parameters is presented. Precontrast T1, M0, and model parameters are estimated jointly, differing from current practice where precontrast T1 and M0 are estimated prior to the model parameters (sequentially). The precision of the two methods were compared using a software phantom capable of simulating realistic abdominal anatomy, contrast enhancement (as modelled with the two-compartment exchange model) and non-linear local motion. Joint estimation led to significant improvements in the precision for all model parameters. In data with motion corruption, significant improvements in precision were observed for estimates of plasma perfusion and relative interstitial volume only.

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