Abstract #2737
Impact of tissue porosity in DCE-MRI: a numerical simulation study
Thomas Perret 1,2 , Clment Debacker 1,2 , Nicolas Pannetier 3,4 , and Emmanuel L Barbier 1,2
1
U836, INSERM, Grenoble, France,
2
Grenoble
Institut des Neurosciences, Universit Joseph Fourier,
Grenoble, France,
3
Radiology,
University of California San Francisco, San Francisco,
California, United States,
4
Center
for Imaging of Neurodegenerative diseases, Veterans
Affairs Medical Centre, San Francisco, California,
United States
Using numerical simulation of DCE-MRI experiments, we
investigated the interstitial space fraction (porosity)
effect on MR signal. The strategy proposed estimates
both permeability and porosity using multiple echo
times. Simulations demonstrate that porosity has a
strong impact on MR signal therefore on permeability
estimates. Results show the feasibility of a method to
obtain improved estimates of permeability and of tissue
porosity.
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