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Abstract #2737

Impact of tissue porosity in DCE-MRI: a numerical simulation study

Thomas Perret 1,2 , Clment Debacker 1,2 , Nicolas Pannetier 3,4 , and Emmanuel L Barbier 1,2

1 U836, INSERM, Grenoble, France, 2 Grenoble Institut des Neurosciences, Universit Joseph Fourier, Grenoble, France, 3 Radiology, University of California San Francisco, San Francisco, California, United States, 4 Center for Imaging of Neurodegenerative diseases, Veterans Affairs Medical Centre, San Francisco, California, United States

Using numerical simulation of DCE-MRI experiments, we investigated the interstitial space fraction (porosity) effect on MR signal. The strategy proposed estimates both permeability and porosity using multiple echo times. Simulations demonstrate that porosity has a strong impact on MR signal therefore on permeability estimates. Results show the feasibility of a method to obtain improved estimates of permeability and of tissue porosity.

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