Abstract #2736
Sources of errors in pharmacokinetic analysis of DCE-MRI
Andre Hallack 1 , Michael A. Chappell 1 , E. Mark Anderson 2 , Fergus V. Gleeson 2 , Mark J. Gooding 3 , and Julia A. Schnabel 1
1
Institute of Biomedical Engineering, Oxford
University, Oxford, United Kingdom,
2
Department
of Radiation Oncology and Biology, Oxford University,
Oxford, United Kingdom,
3
Mirada
Medical, Oxford, United Kingdom
This work presents a study on relaxation time (T
10
)
estimation on variable flip angle SPGR sequences for
pharmacokinetic analysis of tumours on DCE-MRI using the
Tofts model. Its aim is to assess the amount of patient
motion found during these acquisitions and its effects
on T
10
, K
trans
and
k
ep
estimation.
21 rectal tumour SPGR sequences were registered to
estimate motion. Moreover, while using synthetic data, T
10
e,
K
trans
and
K
ep
estimation
error was evaluated for various degrees of deformation.
Overall, an average motion of 0.42mm was found, which
translates into 10% T
10
, 16% K
trans
and
5% k
ep
mean
error.
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