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Abstract #2736

Sources of errors in pharmacokinetic analysis of DCE-MRI

Andre Hallack 1 , Michael A. Chappell 1 , E. Mark Anderson 2 , Fergus V. Gleeson 2 , Mark J. Gooding 3 , and Julia A. Schnabel 1

1 Institute of Biomedical Engineering, Oxford University, Oxford, United Kingdom, 2 Department of Radiation Oncology and Biology, Oxford University, Oxford, United Kingdom, 3 Mirada Medical, Oxford, United Kingdom

This work presents a study on relaxation time (T 10 ) estimation on variable flip angle SPGR sequences for pharmacokinetic analysis of tumours on DCE-MRI using the Tofts model. Its aim is to assess the amount of patient motion found during these acquisitions and its effects on T 10 , K trans and k ep estimation. 21 rectal tumour SPGR sequences were registered to estimate motion. Moreover, while using synthetic data, T 10 e, K trans and K ep estimation error was evaluated for various degrees of deformation. Overall, an average motion of 0.42mm was found, which translates into 10% T 10 , 16% K trans and 5% k ep mean error.

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