Abstract #2735
Brain blood volume assessment using DCE in comparison to DSC methods
Moran Artzi 1,2 , Guy Nadav 1,3 , Gilad Liberman 1 , Orna Aizenstein 1 , and Dafna Ben Bashat 1,4
1
Functional Brain Center, Tel Aviv Sourasky
Medical Center, Tel Aviv, Israel,
2
Sackler
Faculty of Medicine, Tel Aviv University, Tel Aviv,
Israel,
3
Faculty
of Engineering, Tel Aviv University, Tel Aviv, Israel,
4
Sackler
Faculty of Medicine and Sagol School of Neuroscience,
Tel Aviv University, Tel Aviv, Israel
Cerebral blood volume (CBV) obtained using DSC is an
important parameter for brain tumor assessment. DCE can
also be used to extract blood plasma volume (Vp). This
study investigated the relationship between DSC-CBV and
DCE-Vp. A high correlation between cerebral DCE-Vp and
DSC-CBV was detected in 22 healthy subjects. In three
patients with brain tumors, similar maps were obtained
with values above the threshold of 1.75, indicating
malignant tumors. These results suggest DCE as
preferable to DSC for blood volume assessment; this
method has high spatial resolution, is less sensitive to
susceptibility artifacts and provides additional
information regarding tissue permeability.
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