Comparing the relative effect of input parameter errors on the accuracy of the pharmacokinetic parameters in Tofts model.

Simulations are presented that aim at assessing the relative effect of input parameters (i.e. parameters describing the Arterial Input Function or the parameters needed to calculate the tissue contrast agent concentration) on the calculated pharmacokinetic parameters in Tofts modelling of DCE-MRI. It highlights the fact that for accurate measurement of the pharmacokinetic parameters, the accuracy of the parameters describing the initial part of the AIF is significantly more important than that of the slow decay, and that an accurate T1 measurement and a correct scaling of the AIF with respect to the tissue concentration is essential for accurate Ktrans measurement.

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