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Abstract #2730

Advanced Analysis of USPIO Injection in Normal Volunteers

Thomas Christen 1 , Deqiang Qiu 1 , Wendy Wei Ni 1 , Heiko Schmiedeskamp 1 , Michael E Moseley 1 , and Greg Zaharchuk 1

1 Department of Radiology, Stanford University, Stanford, California, United States

It has been recently suggested that following a bolus of contrast agent (CA) with a combined spin- and gradient-echo sequence can bring valuable information about vessel architecture and oxygenation. While promising, the approach might however suffer from low signal to noise ratio as well as contrast agent leakage if a gadolinium based CA is used. As an alternative, we propose to follow an injection of ferumoxytol, an FDA-approved ultra-small paramagnetic iron oxide (USPIO) compound. We scanned 10 volunteers to study the feasibility of approach and combined the results with bolus perfusion and quantitative BOLD analyses.

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