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Abstract #2729

Slice Accelerated Gradient-Echo Spin-Echo Dynamic Susceptibility Contrast Imaging with blipped CAIPI for Increased Slice Coverage

Cornelius Eichner 1,2 , Kourosh Jafari-Khouzani 1 , Stephen Cauley 1 , Himanshu Bhat 3 , Pavlina Polaskova 1 , Ovidiu C Andronesi 1 , Otto Rapalino 1 , Robert Turner 2 , Lawrence L Wald 1 , Steven Stufflebeam 1 , and Kawin Setsompop 1

1 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Saxony, Germany, 3 Siemens Healthcare Sector, Boston, MA, United States

Gadolinium contrast based dynamic susceptibility contrast (DSC) MRI of combined gradient and spin echo (GESE) is an important clinical method to quantify perfusion in healthy and tumorous brain tissue. High temporal sampling is necessary to sufficiently resolve bolus passage, however limits slice-coverage. This work proposes a blipped CAIPI simultaneous-multiple-slice (SMS) method to improve slice range. DSC data with and without SMS were acquired on three tumor patients. SMS DSC with two-fold slice acceleration achieves similar SNR and perfusion metrics as standard acquisitions, whilst allowing doubled slice coverage. The results also point to improved temporal sampling rate with constant slice-coverage.

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