Abstract #2729
Slice Accelerated Gradient-Echo Spin-Echo Dynamic Susceptibility Contrast Imaging with blipped CAIPI for Increased Slice Coverage
Cornelius Eichner 1,2 , Kourosh Jafari-Khouzani 1 , Stephen Cauley 1 , Himanshu Bhat 3 , Pavlina Polaskova 1 , Ovidiu C Andronesi 1 , Otto Rapalino 1 , Robert Turner 2 , Lawrence L Wald 1 , Steven Stufflebeam 1 , and Kawin Setsompop 1
1
Athinoula A. Martinos Center for Biomedical
Imaging, Massachusetts General Hospital, Harvard Medical
School, Boston, MA, United States,
2
Max
Planck Institute for Human Cognitive and Brain Sciences,
Leipzig, Saxony, Germany,
3
Siemens
Healthcare Sector, Boston, MA, United States
Gadolinium contrast based dynamic susceptibility
contrast (DSC) MRI of combined gradient and spin echo (GESE)
is an important clinical method to quantify perfusion in
healthy and tumorous brain tissue. High temporal
sampling is necessary to sufficiently resolve bolus
passage, however limits slice-coverage. This work
proposes a blipped CAIPI simultaneous-multiple-slice (SMS)
method to improve slice range. DSC data with and without
SMS were acquired on three tumor patients. SMS DSC with
two-fold slice acceleration achieves similar SNR and
perfusion metrics as standard acquisitions, whilst
allowing doubled slice coverage. The results also point
to improved temporal sampling rate with constant
slice-coverage.
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