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Abstract #2731

Mapping blood volume fraction and vessel size index at steady-state: Impact of contrast agent dose and spin-echo time

Benjamin Lemasson 1 , Nicolas Pannetier 2 , Thomas Christen 3 , Greg Zaharchuk 3 , Norbert Schuff 2 , and Emmanuel Barbier 1

1 U836, Iserm, Grenoble, France, 2 Va medical center, Centre for neurodegenerative des eases, San Francisco, CA, United States, 3 Stanford University, Department of Radiology, Stanford, CA, United States

Cerebral blood volume fraction (BVf) and vessel size index (VSI) can be mapped with a steady-state approach. To optimize the protocol in the brain, we evaluated the impact of three different doses of contrast agent and three different MRI sequences on the results obtained in healthy rats (n=5). When mapping BVf and VSI at 4.7T, the use of an echo time beyond 60ms decreases the CNR. Regarding the CA dose, no significant changes has been observed on BVf map whereas the use of 200mol of Fe/kg yields the best CNR at the Spin-echo time but two-third of the dose appears almost equivalent in term of CNR.

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