Abstract #2651
Repeatability of Diffusion-Weighted MRI Parameters in a Paediatric Oncology Population
Neil P Jerome 1 , Keiko Miyazaki 1 , David J Collins 1 , Matthew R Orton 1 , James d'Arcy 1 , Lucas Moreno 2 , Andrew D J Pearson 2 , Lynley V Marshall 2 , Fernando Carcellar 2 , Martin O Leach 1 , Stergios Zacharoulis 2 , and Dow-Mu Koh 3
1
CR-UK and EPSRC Cancer Imaging Centre, The
Institute of Cancer Research, Sutton, Surrey, United
Kingdom,
2
Paediatric
Drug Development Team, Cancer Therapeutics and Clinical
Studies, The Institute of Cancer Research, Sutton,
Surrey, United Kingdom,
3
Department
of Radiology, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom
Diffusion-weighted imaging provides a sensitive way of
detecting functional changes that may precede changes in
tumour size and in response to cytostatic effects;
though widely used for functional imaging in adult
clinical trials, there is a need to establish the
repeatability of DWI-derived parameters in children. For
a paediatric cohort (median age 11, range 6 15 years)
of seven extra- and eight intra-cranial solid tumours,
DWI was performed on two successive days, showing lowest
CV values for ADC with varying b-value inclusion (CV 2.4
4.1%), and for D derived from IVIM (CV 2.5%. IVIM
perfusion-related parameters were less repeatable
(CV>25%).
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