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Abstract #2651

Repeatability of Diffusion-Weighted MRI Parameters in a Paediatric Oncology Population

Neil P Jerome 1 , Keiko Miyazaki 1 , David J Collins 1 , Matthew R Orton 1 , James d'Arcy 1 , Lucas Moreno 2 , Andrew D J Pearson 2 , Lynley V Marshall 2 , Fernando Carcellar 2 , Martin O Leach 1 , Stergios Zacharoulis 2 , and Dow-Mu Koh 3

1 CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Paediatric Drug Development Team, Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3 Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom

Diffusion-weighted imaging provides a sensitive way of detecting functional changes that may precede changes in tumour size and in response to cytostatic effects; though widely used for functional imaging in adult clinical trials, there is a need to establish the repeatability of DWI-derived parameters in children. For a paediatric cohort (median age 11, range 6 15 years) of seven extra- and eight intra-cranial solid tumours, DWI was performed on two successive days, showing lowest CV values for ADC with varying b-value inclusion (CV 2.4 4.1%), and for D derived from IVIM (CV 2.5%. IVIM perfusion-related parameters were less repeatable (CV>25%).

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