Abstract #2650
Predicting the Quantitative Accuracy of In-Vivo ADC using an Ice-Water Phantom
David M. Morris 1 , Hossein Ragheb 1 , Neil Thacker 1 , Naomi H.M. Douglas 2 , and Alan Jackson 3
1
Centre for Imaging Sciences, University of
Manchester, Manchester, United Kingdom,
2
Institute
of Cancer Research, Sutton, United Kingdom,
3
Wolfson
Molecular Imaging Centre, University of Manchester,
Manchester, United Kingdom
Apparent diffusion Coefficient (ADC) is a biomarker
shown to have efficacy in monitoring the response of
tumors to interventions. To be used successfully in
multi-center trials a quality assurance protocol must be
developed using an ice water phantom. The results of a
multi-vendor, multi-site trial using standardized
protocols are presented where different measurements of
the accuracy of the systems using the phantom are
compared. Then the relationship of these with the
variability observed within the normal liver of
volunteers at each site. While the protocols can
differentiate between scanners there is no predictive
power for performance
in-vivo
.
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