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Abstract #2570

Construction of ground-truth data for head motion correction in diffusion MRI

Jan Hering 1,2 , Peter F. Neher 1 , Hans-Peter Meinzer 1 , and Klaus H. Maier-Hein 1,3

1 Div. Medical and Biological Informatics, German Cancer Research Center, Heidelberg, Germany, 2 Mannheim University of Applied Sciences, Mannheim, Germany, 3 Quantitative Image-based Disease Characterization, German Cancer Research Center, Heidelberg, Germany

Retrospective head motion correction counts to the most important post-processing steps in diffusion-weighted MR. However, due to the missing ground-truth, a quantitative evaluation of correction algorithms is possible only to a limited extent. Usage of reference transforms applied to an already aligned data is restricted to translation, as the diffusion signal is not invariant under rotation. We present a novel method for construction of ground-truth head motion data using the Fiberfox tool for realistic diffusion-weighted signal simulation. We further show that the rotation must not be neglected in motion correction and evaluation.

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