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Abstract #2569

Motion and eddy-current correction in high b-value diffusion MRI: Systematic registration errors and how to avoid them

Markus Nilsson 1 , Filip Szczepankiewicz 2 , Danielle van Westen 3 , and Oskar Hansson 4

1 Lund University Bioimaging Center, Lund University, Lund, Sweden, 2 Dept. of Medical Radiation Physics, Lund University, Sweden, 3 Dept. of Diagnostic Radiology, Lund University, Sweden, 4 Clinical Memory Research Unit, Dept. of Clinical Sciences Malm, Lund University, Sweden

Motion correction of high b-value diffusion MRI data can be performed using the non-diffusion weighted image as reference, but here we show that this conventional motion correction leads to substantial registration errors in terms of misalignment between low and high b-value volumes. We suggest a method that can eliminate this registration error by extrapolating reference volumes from low b-value data to high b-value data. The improved motion correction leads to a reduction in the standard deviation in the FA of up to 40%, which is associated to a large increase in the statistical power of group studies.

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