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Abstract #2568

Strategies for improved correction of EPI distortions in diffusion MRI with blip-up blip-down acquisitions

Mustafa Okan Irfanoglu 1,2 , Amritha Nayak 1,2 , Andrew Knutsen 3 , Pooja Modi 1 , Joelle Sarlls 3 , and Carlo Pierpaoli 1

1 NICHD, NIH, Bethesda, MD, United States, 2 CNRM, USUHS, Bethesda, MD, United States, 3 NIH, Bethesda, MD, United States

In this work, we propose a novel EPI distortion correction scheme for diffusion weighted images with reversed phase encoding gradient schemes. In addition to describing the proposed method and comparing to existing methodologies, we highlight several important factors affecting these blip-up blip-down corrections and analyze the effects of these factors. Our analysis indicated that using additional anatomical image information helps the registration under imperfect data conditions and that using diffusion weighted image contrast along with b=0 s/mm2 image significantly improves anatomical accuracy, especially in tightly packed regions such as the brain stem.

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