Meeting Banner
Abstract #2552

A comparison of two sequences for spectral imaging of 19 F-containing emulsions

Rik PM Moonen 1,2 , Gustav J Strijkers 1,2 , Abdallah Motaal 1,2 , Rolf Lamerichs 2,3 , Muhammed Yildirim 4 , Erica Aussems-Custers 2,3 , Holger Gruell 1,3 , Martijn Wolters 5 , Eline ME Kooi 5 , Christoph Jacoby 6 , Ulrich Flgel 6 , and Klaas Nicolay 1,2

1 Biomedical Engineering/Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Center for Imaging Research & Education (CIRE), Eindhoven, Netherlands, 3 Philips Research, Eindhoven, Netherlands, 4 Philips Healthcare, Best, Netherlands, 5 Department of Radiology, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands, 6 Institut fr Molekulare Kardiologie, Heinrich-Heine-Universitt, Dsseldorf, Germany

Two accelerated 19 F MRI sequences, Multiple Chemical Shift Selective RARE (MCSS-RARE) and Fluorine ultrafast Turbo Spectroscopic Imaging (FuTSI) were compared for their ability to image multiple 19 F resonances of perfluorocarbon (PFC) emulsions. MCSS-RARE is spectrally selective, whereas FuTSI has a spectral read-out. The MCSS-RARE sequence proved superior in terms of scan speed and SNR. Both sequences enabled spectral imaging of 19 F resonances in liver and spleen of ApoE-/- mice injected with PFOB emulsion, but failed to visualize PFOB accumulation in plaques in vivo. Ex vivo MCSS-RARE imaging did reveal 19 F resonances at major plaque sites.

This abstract and the presentation materials are available to members only; a login is required.

Join Here