Abstract #2551
MRI Evaluation of Coronary Versus Systemic Endothelial Function in Healthy Subjects and Patients with Coronary Artery Disease
Rupa Krishnaswamy 1 , Gary Gerstenblith 1 , Sahar Soleimanifard 2 , Michael Schar 3 , Matthias Stuber 4 , and Robert G Weiss 5
1
Medicine, Johns Hopkins University,
Baltimore, MD, United States,
2
Biomedical
Engineering, Johns Hopkins University, Baltimore, MD,
United States,
3
Radiology,
Johns Hopkins University, Baltimore, MD, United States,
4
Radiology,
Centre Hospitalier Univ Vaudois, Lausanne, Switzerland,
Switzerland,
5
Medicine,
Radiology, Johns Hopkins Univ, MD, United States
We have used non-invasive 3T MRI with isometric handgrip
exercise (IHE) to evaluate endothelial function of two
physiologically different vascular beds (coronary and
systemic) in healthy subjects and patients with coronary
artery disease (CAD). Using this methodology,
endothelial-dependent response of coronary and systemic
vasculature can be assessed in the same person, and
sometimes within the same MRI acquisition. We have
confirmed that coronary vasodilation does not occur in
patients with CAD, and demonstrated that the internal
mammary artery exhibits a greater degree of vasodilation
with IHE than the right coronary artery in patients with
CAD.
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