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Abstract #2313

Backflow variability shows importance of MR monitoring of CED infusions

Ethan K. Brodsky 1,2 , Benjamin Grabow 1 , Martin L. Brady 3 , Raghu Raghavan 3 , Chris D. Ross 4 , and Walter F. Block 1,2

1 Medical Physics, University of Wisconsin, Madison, WI, United States, 2 Biomedical Engineering, University of Wisconsin, Madison, WI, United States, 3 Therataxis, LLC, Baltimore, MD, United States, 4 Engineering Resources Group, Inc., Pembroke Pines, FL, United States

Convection-enhanced delivery (CED) is a neurosurgical procedure for delivering large molecular and viral vectors into the brain. Its effectiveness has been somewhat limited, however, by unexplained variability, with two identical infusion protocols sometimes generating very different drug distributions. We have completed a comprehensive study on the use of real-time MR monitoring to unravel often conflicting recommendations on the design of infusion catheters, flow rates, and other techniques to minimize variance in drug distribution. Specifically, we present results here regarding an investigation to minimize variations in drug distribution due to unwanted loss of infusate through a low pressure escape route along the exterior of the catheter, termed backflow.

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