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Abstract #2312

In vivo Assessment of initial Thymus Size and Age-related Thymic Involution in a C57BL/6J Mouse Strain

Abdel Wahad Bidar 1 , Marie Ramnegrd 2 , Rebecka Svrd 2 , Janeli Sarv 3 , Sofia Tapani 3 , Josefin Forsberg 4 , Amir Smailagic 2 , Thomas G. Hansson 2 , and Johan Jirholt 2

1 R&D Personalised Healthcare & Biomarkers - Imaging, AstraZeneca, Mlndal, Sweden, 2 RIA Innovative medicine, AstraZeneca, Mlndal, Sweden, 3 Discovery Sciences statistics, AstraZeneca, Mlndal, Sweden, 4 DSM laboratory animal, AstraZeneca, Mlndal, Sweden

The C57BL/6J mouse strain can serve as a convenient model for investigations of immune-based therapeutics that can enhance thymic function. In this study we demonstrate for the first time in vivo by means of MRI the natural growth and involution pattern of the thymus in a group of C57BL/6J male and female mice. Male thymus involution started before mice reached 5 weeks of age and persisted up to 8 weeks. Female thymus volume reached its maximum when mice reached 6-7 weeks old and was followed by a rapid involution rate up to an age of 10 weeks.

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