Abstract #2312
In vivo Assessment of initial Thymus Size and Age-related Thymic Involution in a C57BL/6J Mouse Strain
Abdel Wahad Bidar 1 , Marie Ramnegrd 2 , Rebecka Svrd 2 , Janeli Sarv 3 , Sofia Tapani 3 , Josefin Forsberg 4 , Amir Smailagic 2 , Thomas G. Hansson 2 , and Johan Jirholt 2
1
R&D Personalised Healthcare & Biomarkers -
Imaging, AstraZeneca, Mlndal, Sweden,
2
RIA
Innovative medicine, AstraZeneca, Mlndal, Sweden,
3
Discovery
Sciences statistics, AstraZeneca, Mlndal, Sweden,
4
DSM
laboratory animal, AstraZeneca, Mlndal, Sweden
The C57BL/6J mouse strain can serve as a convenient
model for investigations of immune-based therapeutics
that can enhance thymic function. In this study we
demonstrate for the first time in vivo by means of MRI
the natural growth and involution pattern of the thymus
in a group of C57BL/6J male and female mice. Male thymus
involution started before mice reached 5 weeks of age
and persisted up to 8 weeks. Female thymus volume
reached its maximum when mice reached 6-7 weeks old and
was followed by a rapid involution rate up to an age of
10 weeks.
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