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Abstract #2314

Novel intervention for acute migraine headache investigated by BOLD fMRI

Tie-Qiang Li 1 , Yanlu Wang 1 , Rolf Hallin 2 , and Jan-Erik Juto 3

1 Department of Medical Physics, Karolinska University Hospital, Huddinge, Stockholm, Sweden, 2 Department of Neurophysiology, Karolinska University Hospital, Huddinge, Stockholm, Sweden, 3 Department of CLINTEC, Karolinska Institute, Huddinge, Stockholm, Sweden

The purpose of the study was to investigate the dynamical functional response in hypothalamus to a novel therapeutic intervention which has been shown to be extraordinarily effective for treating migraine headache and narcolepsy. BOLD fMRI experiments were carried out under a non-invasive intervention for clinical patients with acute migraine headache attack. The BOLD responses under different interventional conditions indicate that restoring the physiological homeostasis in hypothalamus and associated functional network at the basal of the brain, which is the control center of the autonomic nervous system (ANS), provides an efficient approach for the treatment of central nervous system disorders.

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